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At Syracuse University

(1) Fu, X.; Zhu, B.; Hu, X.* “Force-Triggered Atropisomerization of a Parallel Diarylethene to Its Anti-Parallel Diastereomers”, J. Am. Chem. Soc. 2023, 145, 15668-15673.


Before Syracuse

•   Husic, C. C.; Hu, X; Robb, M. J. “Incorporation of a Tethered Alcohol Enables Efficient Mechanically Triggered Release in Aprotic Environments”, ACS Macro Lett. 2022, 11, 948-953.

•   Versaw, B; Zeng, T; Hu, X; Robb, M. J. “Harnessing the Power of Force: Development of Mechanophores for Molecular Release”, J. Am. Chem. Soc. 2021, 143, 21461-21473.

•   Zeng, T; Hu, X; Robb, M. J. “5-Aryloxy Substitution Enables Efficient Mechanically Triggered Release from a Synthetically Accessible Masked 2-Furylcarbinol Mechanophore”, Chem. Commun., 2021, 57, 11173-11176.

•   Hu, X; Zeng, T; Husic, C. C.; Robb, M. J. “Mechanically Triggered Release of Functionally Diverse Molecular Payloads from Masked 2-Furylcarbinol Derivatives”, ACS Cent. Sci. 2021, 7, 1216-1224.

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•   Hu, X; Zeng, T; Husic, C. C.; Robb, M. J. “Mechanically Triggered Small Molecule Release from a Masked Furfuryl Carbonate”, J. Am. Chem. Soc. 2019, 141, 15018-15023.

Selected Highlights: Caltech NewsJACS Spotlights

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• Barber, R. W.; McFadden, M. E.; Hu, X.; and Robb, M. J. “Mechanochemically Gated Photoswitching: Expanding the Scope of Polymer Mechanochromism”, Synlett 2019, 30, 1725–1732.

Hu, X.; McFadden, M. E.; Baber, R. W.; Robb, M. J. “Mechanochemical Regulation of a Photochemical Reaction”, J. Am. Chem. Soc. 2018, 140, 14073-14077.

Selected Highlights: Research Highlight by Nature Reviews Chemistry

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• Feeney M. J.; Hu, X.; Srinivasan R.; Van N.; Hunter M.; Georgakoudi I.; Thomas S. W. III “UV and NIR-Responsive Layer-by-Layer Films Containing 6-Bromo-7-hydroxycoumarin Photolabile Groups”, Langmuir 2017, 33, 10877–10885.

Hu, X.; Lawrence, J. A.; Mullahoo, J.; Smith, Z. C; Wilson, D. J.; Mace, C. R.; Thomas, S. W. III “Directly Photopatternable Polythiophene as Dual-Tone Photoresist”, Macromolecules 2017, 50, 7258–7267.

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• Kaner, P.; Hu, X.; Thomas, S. W. III, Asatekin, A. “Self-Cleaning Membranes from Comb-Shaped Copolymers with Photoresponsive Side Groups”, ACS Appl. Mater. Interfaces 2017, 9, 13619–13631.

Hu, X.; Qureishi, Z.; Thomas, S. W. III "Light-Controlled Selective Disruption, Multi-Level Patterning, and Sequential Release with Polyelectrolyte Multilayer Films Incorporating Four Photocleavable Chromophores”, Chem. Mater. 2017, 29, 2951-2960.

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Hu, X.; Feeney, M. J.; McIntosh, E.; Mullahoo, J.; Jia, F.; Xu, Q.; Thomas, S. W. III "Triggered Release of Encapsulated Cargo from Photoresponsive Polyelectrolyte Nanocomplexes", ACS Appl. Mater. Interfaces 2016, 8, 23517–23522.

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Hu, X.; Macintosh, E; Simon, M. G.; Staii, C.; Thomas, S. W. III "Stimuli-Responsive Free-Standing Layer-By-Layer Films", Adv. Mater. 2016, 28, 715–721.

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• Hu, X.; Shi, J.; Thomas, S. W. III "Photolabile ROMP Gels Using ortho-Nitrobenzyl Functional Crosslinkers”, Polym. Chem. 2015, 6, 4966–4971.

Polymer Chem 2015.PNG

• Gumbley, P.; Hu, X.; Lawrence, J. A., III; Thomas, S. W. III "Photoresponsive Gels Prepared by Ring Opening Metathesis Polymerization”, Macromol. Rapid Commun. 2013, 34, 1838–1843.


  • Hu, X.; Fu, X. "Mechanophore with Force Triggered Chirality Conversion". Provisional Patent App. 63/464,213, May 5, 2023. (Syracuse University)

  • Robb, M. J.; Hu, X.; Zeng, T. “Method for Controlled Release Using Mechanical Force”. US11584752B2t, Granted February 21, 2023. (California Institute of Technology)

  • Hu, X.; Zhu, S.; Robisson, A.; Qu, M; Ossia, S. “Methods for Ring-Opening Metathesis Polymerization (ROMP) for In-Situ Formation of High Glass Transition Temperature (Tg) Polymers”. US11,377,580, Granted July 5, 2022. (Schlumberger Technology Corporation)

  • Asatekin, A.; Thomas, S. W. III; Kaner, P.; Hu, X. “Two-layer photo-responsive membranes”. US10,603,637, Granted March 31, 2020. (Tufts University)

  • Robb, M. J.; Hu, X. “Mechanical Regulation of Photoswitching”. US Patent App. 17/019,107, published March 11, 2021. (California Institute of Technology)

  • Luozhong, S.; Yuan, Z.; Jiang, S.; Hu, X.; Bailey, S. "Zwitterionic lipid nanoparticle compositions, and methods of use". US Patent App. 63/129,343, published June 30, 2022. (Cornell)

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