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Publications

At Syracuse University

3. Fu, X.; Hu, X.* "Ultrasound-Controlled Prodrug Activation: Emerging Strategies in Polymer Mechanochemistry and Sonodynamic Therapy" ACS Applied Bio Materials 2024 in press.

2. Zhang, C.; Fu, X.; Hu, X.* “Harnessing the Conformer/Atropisomer-Dependent Photochromism of Diarylethene Photoswitches and Forcing a Diarylethene Atropisomer to Its Configurational Diastereomers with Polymer Mechanochemistry” Synlett 2024 in press (invited Synpacts) DOI: 10.1055/s-0042-1751536​

1. Fu, X.; Zhu, B.; Hu, X.* “Force-Triggered Atropisomerization of a Parallel Diarylethene to Its Anti-Parallel Diastereomers” J. Am. Chem. Soc.   2023, 145, 15668-15673.   doi.org/10.1021/jacs.3c03994

diarylethene mechanophore conformer atropisomer atropisomerization sterechemistry configuration

Featured in: Synfacts

Before Syracuse University

•   Husic, C. C.; Hu, X; Robb, M. J. “Incorporation of a Tethered Alcohol Enables Efficient Mechanically Triggered Release in Aprotic Environments”, ACS Macro Lett. 2022, 11, 948-953.

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•   Versaw, B; Zeng, T; Hu, X; Robb, M. J. “Harnessing the Power of Force: Development of Mechanophores for Molecular Release” J. Am. Chem. Soc. 2021, 143, 21461-21473.

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•   Zeng, T; Hu, X; Robb, M. J. “5-Aryloxy Substitution Enables Efficient Mechanically Triggered Release from a Synthetically Accessible Masked 2-Furylcarbinol Mechanophore” Chem. Commun., 2021, 57, 11173-11176.

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•   Hu, X; Zeng, T; Husic, C. C.; Robb, M. J. “Mechanically Triggered Release of Functionally Diverse Molecular Payloads from Masked 2-Furylcarbinol Derivatives” ACS Cent. Sci. 2021, 7, 1216-1224. doi.org/10.1021/acscentsci.1c00460

furan maleimide diels-alder adduct mechanophore mechanically triggered release

•   Hu, X; Zeng, T; Husic, C. C.; Robb, M. J. “Mechanically Triggered Small Molecule Release from a Masked Furfuryl Carbonate” J. Am. Chem. Soc. 2019, 141, 15018-15023. doi.org/10.1021/jacs.9b08663

Featured in Caltech News

Featured in JACS Spotlights

furan maleimide diels-alder adduct mechanophore mechanically triggered release

• Barber, R. W.; McFadden, M. E.; Hu, X.; and Robb, M. J. “Mechanochemically Gated Photoswitching: Expanding the Scope of Polymer Mechanochromism” Synlett 2019, 30, 1725–1732.

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• Hu, X.; McFadden, M. E.; Baber, R. W.; Robb, M. J. “Mechanochemical Regulation of a Photochemical Reaction” J. Am. Chem. Soc. 2018, 140, 14073-14077.  doi.org/10.1021/jacs.8b09628

Featured in Nature Reviews Chemistry

Diarylethene mechanophore mechanically gated photoswitch

• Feeney M. J.; Hu, X.; Srinivasan R.; Van N.; Hunter M.; Georgakoudi I.; Thomas S. W. III “UV and NIR-Responsive Layer-by-Layer Films Containing 6-Bromo-7-hydroxycoumarin Photolabile Groups” Langmuir 2017, 33, 10877–10885.

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• Hu, X.; Lawrence, J. A.; Mullahoo, J.; Smith, Z. C; Wilson, D. J.; Mace, C. R.; Thomas, S. W. III “Directly Photopatternable Polythiophene as Dual-Tone Photoresist” Macromolecules 2017, 50, 7258–7267. doi.org/10.1021/acs.macromol.7b01208

Photolithography photoresist p3ht nitrobenzyl polymer patterning

• Kaner, P.; Hu, X.; Thomas, S. W. III, Asatekin, A. “Self-Cleaning Membranes from Comb-Shaped Copolymers with Photoresponsive Side Groups” ACS Appl. Mater. Interfaces 2017, 9, 13619–13631.

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• Hu, X.; Qureishi, Z.; Thomas, S. W. III "Light-Controlled Selective Disruption, Multi-Level Patterning, and Sequential Release with Polyelectrolyte Multilayer Films Incorporating Four Photocleavable Chromophores” Chem. Mater. 2017, 29, 2951-2960.   doi.org/10.1021/acs.chemmater.6b05294

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photopatternable layer-by-layer polyelectrolyte film nanofilm

• Hu, X.; Feeney, M. J.; McIntosh, E.; Mullahoo, J.; Jia, F.; Xu, Q.; Thomas, S. W. III "Triggered Release of Encapsulated Cargo from Photoresponsive Polyelectrolyte Nanocomplexes" ACS Appl. Mater. Interfaces 2016, 8, 23517–23522.  doi.org/10.1021/acsami.6b07366

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photoresponsive polyelectrolyte nanoparticles

• Hu, X.; Macintosh, E; Simon, M. G.; Staii, C.; Thomas, S. W. III "Stimuli-Responsive Free-Standing Layer-By-Layer Films" Adv. Mater. 2016, 28, 715–721. doi.org/10.1002/adma.201504219

photoresponsive nanofilm freestanding

• Hu, X.; Shi, J.; Thomas, S. W. III "Photolabile ROMP Gels Using ortho-Nitrobenzyl Functional Crosslinkers” Polym. Chem. 2015, 6, 4966–4971.  doi.org/10.1039/C5PY00562K

photoresponsive romp gel nitrobenzyl

• Gumbley, P.; Hu, X.; Lawrence, J. A., III; Thomas, S. W. III "Photoresponsive Gels Prepared by Ring Opening Metathesis Polymerization” Macromol. Rapid Commun. 2013, 34, 1838–1843.

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Patents

  • Robb, M. J.; Hu, X. “Mechanical Regulation of Photoswitching” US11834442B2, Granted December 5, 2023. (California Institute of Technology)

  • Hu, X.; Fu, X. "Mechanophore with Force Triggered Chirality Conversion" Provisional Patent App. 63/464,213, May 5, 2023. (Syracuse University)

  • Robb, M. J.; Hu, X.; Zeng, T. “Method for Controlled Release Using Mechanical Force” US11584752B2t, Granted February 21, 2023. (California Institute of Technology)

  • Hu, X.; Zhu, S.; Robisson, A.; Qu, M; Ossia, S. “Methods for Ring-Opening Metathesis Polymerization (ROMP) for In-Situ Formation of High Glass Transition Temperature (Tg) Polymers” US11,377,580, Granted July 5, 2022. (Schlumberger Technology Corporation)

  • Luozhong, S.; Yuan, Z.; Jiang, S.; Hu, X.; Bailey, S. "Zwitterionic lipid nanoparticle compositions, and methods of use" US Patent App. 63/129,343, published June 30, 2022. (Cornell)

  • Asatekin, A.; Thomas, S. W. III; Kaner, P.; Hu, X. “Two-layer photo-responsive membranes” US10,603,637, Granted March 31, 2020. (Tufts University)

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